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Liu Y, Ge DL, Zhou JJ, Chu YJ, Zheng XX, Ke L, et al

The largest of these studies1 is a prospective cohort study conducted in the United States and United Kingdom that found that children with prenatal exposure to valproate (n=62) had lower IQ scores at age 6 (97 [95% CI 94-101]) than children with prenatal exposure to the other antiepileptic drug monotherapy treatments evaluated: lamotrigine (108 [95% CI 105110]), carbamazepine (105 [95% CI 102108]), and phenytoin (108 [95% CI 104112])