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In addition, EVs derived from M2-type macrophages promoted glutamine metabolism in osteoclast precursors (OCPs) by transporting glutamate, causing an increase in alpha-KG and inducing metabolic reprogramming [127]

Moreover, ApoE, the primary lipid transporter in the brain, significantly affects lipid homeostasis and A clearance, with the ApoE4 allele being the strongest genetic risk factor for late-onset AD (Husain et al., 2021)