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The proposal of innovative concepts such as core probiotic-targeted therapy marks the transition of microbial therapeutics from empirical exploration to precision targeting (Fang et al., 2025)

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Crucially, the ROS generated during GSH degradation by CHAC1 may also cause further TP53 mutations, creating a vicious self-reinforcing cycle: CHAC1 activity promotes the very TP53 mutations that allow the tumor to exploit CHAC1s harmful effect for growth

The unidimensional proton NMR spectra were converted into matrices (AMIX 3.9.14, Bruker Biospin, Rheinstetten, Germany), excluding methanol ( 3.36, singlet) and water ( 4.45.4) spectral regions