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Expanding the clinicopathologic and molecular spectrum of BCOR-associated sarcomas in adults

Apoptosis can be triggered by endoplasmic reticulum (ER) stress in which glucose-regulated protein 78 (GRP78), CCAAT-enhancer-binding protein homologous protein (CHOP) and activating transcription factor 4 (ATF4) are induced by unfold protein response (UPR) to ameliorate ER stress by stimulation of apoptosis (Di Conza and Ho, 2020)

They are all closely dependant on each other, so the absence of one will critically effect the activity of all others

Ultimately, anyone considering BPC-157 should weigh the benefits against the limited regulatory framework and incomplete clinical research