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Host-related factors encompass various determinants, such as age, gender, genetic predisposition, underlying medical comorbidities, and the level of immunosuppression

RTKs are a class of transmembrane receptor proteins that bind specific growth factors or hormones through their external structural domains, activating their intrinsic tyrosine kinase activity

In addition to these catalytic properties, some GSTs possess the property to bind ligands also referred to as ligandin properties

However, age-related declines in antioxidant capacity can reduce this protection, creating a vicious cycle where hemoglobin dysfunction contributes to further oxidative stress and systemic aging [36]