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6-Shogaol as a novel thioredoxin reductase inhibitor induces oxidative-stress-mediated apoptosis in HeLa cells

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Cortisol dysregulation also becomes more pronounced as estrogen withdrawal activates the HPA axis, producing the elevated baseline stress-hormone output that drives the "tired but wired" pattern common in midlife women

This is particularly important in thalassemia, because a patient with transfusion-related iron burden cannot be handled in the same way as a weak but non-transfusion-dependent patient