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Chorioretinal anastomosis or subretinal neovascularization can occur over healing lesions ( Figure 10.12 , GK)

For example, studies on low-dose cadmium exposure report both significant associations with prostate and kidney cancers [294,295] and null findings in other cohorts [296,297], highlighting limitations due to small sample sizes, exposure misclassification, or regional differences

While this research is extensive and consistently positive, the gap between animal and human studies represents both a limitation of current knowledge and an opportunity for future research

As a result, the expression of ALDH3A1 and hypoxia-inducible factor-1 (HIF-1) were significantly boosted in a hypoxia time-dependent manner (Fig