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3.1 PK Interactions Although drug interactions between psychotropic medications and COVID-19 therapies may theoretically involve each of the four PK ADME (absorption, distribution, metabolism, and elimination) phases [30], the most relevant mechanisms concern metabolic activity on the CYP microsomal system and drug transporters (mainly P-gp) according to lipophilic properties of psychotropic agents [26, 31, 32]

Kim Y, Li E, Park S (2012) Insulin-like growth factor-1 inhibits 6-hydroxydopamine-mediated endoplasmic reticulum stress-induced apoptosis via regulation of heme oxygenase-1 and Nrf2 expression in PC12 cells

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B., Rehnstrm, J