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Description

Wnt ligands bind to Frizzled receptors on the cell surface, resulting in the increased stability of cytoplasmic -catenin, and its subsequent translocation into the nucleus, where it activates the transcription of MITF by interplay with lymphoid enhancer-binding factor 1 (LEF1)/T-cell factor (LEF1/TCF) (26)

Bank, U

et al., 2022), conducted a screening of phenazine library compounds targeting breast cancer stem cells and identified three compounds (CPUL119, CPUL129, and CPUL149)