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10.1016/j.cell.2015.01.003 73 O'BrienL

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Khavinson's group reported improved immune parameters and reduced respiratory infection rates in elderly cohorts receiving thymalin over 6-8 year observation periods Longevity data: A 15-year observational study of elderly patients receiving thymalin and epithalamin reported reduced mortality compared to untreated controls, with significant reductions in cardiovascular, cancer, and infectious disease mortality COVID-19 observations: During the pandemic, Khavinson's group published observations suggesting improved outcomes in elderly COVID-19 patients receiving thymalin, though these were not randomized controlled trials Evidence Assessment# Thymalin has the longest clinical history of any bioregulator, with decades of use in Russian medicine

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