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In cancer, polyunsaturated fatty acids (PUFAs) have been shown to disrupt normal myelopoiesis in the bone marrow of tumor-bearing mice, leading to an increased accumulation and enhanced activity of PMN-MDSCs via the JAK/STAT3 signaling pathway [33]

Compound heterozygotes with severe deficient Z allele were reported to have an increased risk of emphysema in adulthood.4 In this case, it is possible that tobacco smoke exposure, coexisting inflammatory disease (atopic asthma), frequent low respiratory tract infections and poor nutritional status have contributed to pulmonary function deterioration and emphysema development at such early age

USA 103 , 1670416709 (2006)