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Conversely, the clinical relevance of TIBC remains uncertain, as high TIBC may indicate low iron stores, reducing overload risk yet potentially impairing cellular functions essential for recovery

Disclosures: Lita Petcharaporn: Nothing to Disclose, Fatma Barakat: Nothing to Disclose, Nothing to Disclose, Tarek Hassanein: Nothing to Disclose 980 THE PNPLA3 I148M VARIANT AGGRAVATES INFLAMMATION IN MACROPHAGES THROUGH IMPAIRED NUCLEAR RECEPTORS (LXR ALPHA, PPAR GAMMA, AND GR ALPHA) SIGNALLING Emmanuel Dixon 1 thierry claudel 1 Jakob-Wendelin Genger 1 Ci Zhu 1 Alexander Nardo 1 Veronika Mlitz 1 Claudia Fuchs 1 Andreas Bergthaler 1 Paola Dongiovanni 2 Wilfried Ellmeier 1 Michael Trauner 1 , 1 Medical University of Vienna, 2 Maggiore Policlinico, Milan Background: Most functional studies linking the single nucleotide polymorphism (rs738409

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