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Both compounds also enhanced BDNF expression and extracellular signal-regulated kinases (ERK), and CREB signaling, which play crucial roles in neurogenesis and cognitive function 23,31,50,56

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The BDNF increase from fasting appears to be related to the switch from glucose to ketone metabolism, as ketone bodies like beta-hydroxybutyrate directly stimulate BDNF gene expression in the hippocampus