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References: ARS Pharma (2024): Comparative Stability of Three Epinephrine Products Under Extreme Temperature Conditions

Thus, glutamatergic excitotoxicity through the kynurenine pathway and related pathways may be a key mechanism by which stress leads to the neurophenotypes commonly identified in depression, including gray matter loss (as measured by smaller limbic volumes, cortical thinning, and lower surface area), lower integrity of white matter microstructure in fronto-cingulate-limbic tracts (LeWinn et al., 2014), and altered intrinsic fronto-cingulate-limbic connectivity (Ho et al., 2014, 2015, 2017b

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