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Additional risks specific to the bodybuilding context include: Cardiovascular strain: Increases in resting heart rate have been observed with GLP-1 receptor agonists as a class (as documented in the Summary of Product Characteristics for licensed agents such as semaglutide and tirzepatide)

This animal equivalent dose (AED) of metformin (4 mg) was calculated in accordance with previously described methods (Nair and Jacob, 2016) based on the human dosage (1000 mg) used in the current clinical study

Furthermore, significant increases in photoreceptor neurodegeneration were observed, raising concerns about the safety of this molecule in the treatment of DR