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Their highly electrophilic N=C=S core reacts readily with many biological nucleophiles 14 , through conjugation to exposed nucleophilic residues and cleavage of disulfide bonds, resulting in the disruption of protein tertiary structures and active sites 15,16

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Vega, University of Oviedo, Spain Reviewed by Cristian Acosta, CONICET Mendoza, Argentina Xiaowei Chen, Ningbo University, China Song Cai, Shenzhen University, China Updates Copyright 2024 Chen, Gan, Au and Ma