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In parallel, butyrate also functions as a histone deacetylase (HDAC) inhibitor, influencing epigenetic gene expression ( reg ) differentiation, induce antimicrobial peptide expression (e.g., -defensins, RegIII), and maintain epithelial barrier integrity (Isobe et al., 2020

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The formulation pairs a stabilized GHRH receptor agonist with a selective growth hormone secretagogue receptor (GHS-R) agonist, allowing concurrent investigation of GHRH and ghrelin / GHS pathway activation