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[2] The MHRA Drug Safety Update (August 2022) advises healthcare professionals to consider testing vitamin B12 levels in patients taking metformin who develop symptoms of neuropathy or anaemia, and to consider periodic monitoring in those at risk of deficiency

It has not completed the clinical trial pathway required for regulatory approval, and there are no active Investigational New Drug (IND) applications filed with the FDA for TB-500 specifically

Semaglutide (Wegovy) is also used to treat metabolic dysfunction-associated steatohepatitis (MASH), without cirrhosis of the liver

It may be used in conditions such as hypogonadotropic hypogonadism, delayed puberty, or certain cases of male infertility where hormonal stimulation is required