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Glutathione supplements are generally well tolerated at the doses used in clinical trials (250-1,000 mg/day for reduced glutathione, 500-1,000 mg/day for liposomal)

2 measured reduced and oxidized hepatic GSH concentrations during alcoholic and nonalcoholic liver injury in 35 chronic alcoholics, 20 nonalcoholic patients with liver disease (chronic active hepatitis, chronic persisting hepatitis, steatosis, cirrhosis), and 15 control patients (admitted for uncomplicated abdominal procedures)

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This selectivity is a primary reason researchers prefer ipamorelin over older growth hormone secretagogue compounds when a clean secretagogue signal is required