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Factors affecting IgG4-mediated complement activation

Specifically, GMTs for neutralization of the pre-immunization (day 1) group increased by 3.1-fold against the wild-type, 3.8-fold against B.1.1.7 (Alpha), 2.3-fold against B.1.351 (Beta), 2.1-fold against P.1 (Gamma), 2.5-fold against BA.1 (Omicron), and 2.9-fold against BA.2 (Omicron) than the co-administration (day 0) group