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1.1.4 Fusion and degradation For an autophagosome to successfully complete its life cycle, it needs to recruit proteins that facilitate travel from the PAS to the perinuclear region, where autophagosomes fuse with lysosomes

Its main functions are detoxification, metabolism, nutrient storage (e.g., iron and vitamins), synthesis of coagulation factors, formation of bile, filtration, and storage of blood

Abstract This review provides a summary of currently available pharmaceutical therapies for the treatment of obesity, along with an overview of the pipeline of products currently in development, and the key mechanisms on which the major development candidates are based

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