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Urolithins: A Comprehensive Update on their Metabolism, Bioactivity, and Associated Gut Microbiota

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established a direct neurotoxic action by acetaminophen both in vitro and in vivo in rats at doses below those required to produce hepatotoxicity and suggested that this neurotoxicity might be involved in the general toxic syndrome observed during patient acetaminophen overdose and, possibly, when acetaminophen doses in the upper dosing schedule are used, especially if other risk factors (moderate alcohol drinking, fasting, nutritional impairment) are present

In adults, the liver was identified as the target of APAP toxicity in the 1960s [6-8]