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Proc Natl Acad Sci U S A 100:62166220 Arafa NM, Marie M-AS, AlAzimi SAM (2016) Effect of canagliflozin and metformin on cortical neurotransmitters in a diabetic rat model

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Conclusion : Inhibiting hepatic Wnt signaling results in lower levels of glutamine and mTOR activity, prompting an increase in autophagy that clears the accumulated porphyrin-protein complexes and helps alleviate porphyria (Figure 1)

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