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In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later

endothelial NOS (NOS3)

Different types of diseases have been reported due to either over or under-expression of GPx1 like hyperglycemia, hyperbilirubinemia and obesity (McClung et al., 2004)