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Conditions of Paradoxical B12 deficiency include Autism Chronic Fatigue Syndrome Hypothyroidism Parkinson's Disease Various malignancies Inflammatory Conditions Various cancers Ulcerative colitis Long Covid Persons with Paradoxical B12 deficiency are more likely to die from COVID-19 Persons with Paradoxical B12 deficiency more likely to die from all cause mortality The current dogma on vitamin B12 deficiency implies a direct link between levels of serum vitamin B12, and sufficiency

Some newer liposomal and acetylated formulations improve bioavailability, but none reliably match the cellular delivery of a doctor-supervised IV protocol

) [2] Presence of serum autoantibodies supports the diagnosis

The 5-Amino-1MQ half life directly informs this strategy