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Chloroquine (CQ) and hydroxychloroquine (HCQ) are antimalarial agents which are thought to impair terminal glycosylation of the virus ACE2, but not affecting the mammalian cell ACE2 and therefore, could be theoretically used in the treatment of COVID-19

Conversely, this auto-oxidation, which is detrimental to the nitrosothiol formation, contributes to the production of highly reactive peroxynitrite resulting from the reaction between superoxide anions and NO

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Methylated CpG islands are typically associated with heterochromatin, partly due to the recruitment of methyl-CpG binding proteins, which in turn recruit histone deacetylases and other chromatin-remodeling complexes to promote transcriptional repression (Hashimoto et al., 2010)