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67 Gao et al demonstrated that the use of CYP2E1 inhibitors reduced NLRP3 signal transduction, caspase-1 expression and ROS production in the liver of mice

In most neurotransmitter receptor interactions, control of response to a "normal" amount of neurotransmitter production is finely tuned so that there is a good balance between the amount of ligand (neurotransmitter) and the numbers of receptors so the cell receives a good response signal

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Moreover, compounds associated with nucleotide metabolism, such as 5-methylthioadenosine, xanthine, and hypoxanthine, were also elevated, alongside phenylalanine metabolism intermediates like phenylacetaldehyde and folate metabolism-related substances including 4-aminobenzoic acid