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Notably, while classical organoid systems have long been established exclusively from crypt-resident stem cells 27,28 , our findings challenge this longstanding paradigm by demonstrating that mutation-free villus-derived cells can indeed establish organoids via fetal reversion, revealing remarkable regenerative flexibility of the adult intestinal epithelium

PSC mainly affects the large bile ducts with a characteristic pattern of multifocal strictures and dilations, while PBC targets small intrahepatic bile ducts

Moreover, it markedly prolonged the inhibition of PFC neurons following electrical stimulation of the ventral tegmental area, which could be prevented using a 5-HT 2A antagonist (Godbout et al., 1991)

Oral administration has the benefit of high patient compliance and has demonstrated the potential to target brain iron pathology, especially with BBB-permeant agents like DFP