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High levels of amino acid in the blood increases the chance of heart disease, sudden death of brain cells, Dementia, and porous bones.The deficiency of B12 in the body may result in pernicious anemia , low red blood cells in the body, tiredness, breathlessness, unusual fast beating of the heart

The conclusion is that the trispecific SAR442257 operates via dual targeting of CD38 and CD28 on myeloma cells and of CD3 and CD28 on T lymphocytes, showing superior MM killing compared to bispecific antibodies