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Cell 2014, 159 (4), 925939

Anti-CD38 antibodies CD38 is a transmembrane glycoprotein expressed at low levels on most myeloid and lymphoid cells, whereas normal and malignant plasma cells exhibit high levels of surface CD38 expression

In future trials it will be important to keep track of comorbidities for clinical trial design, either for the purpose of post hoc subgroup analysis or a priori subgroup recruitment, since the neuroathophysiological mechanisms in IC/ BPS patients with different co-morbidities are likely to be different

Individuals with Leber's hereditary optic neuropathy should avoid cyanocobalamin formulations, as there is evidence suggesting potential harm