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In hepatocellular carcinoma (HCC) cells, post-translational activation of cystathionine -synthase (CBS) under TNF-induced oxidative stress increases TSS activity through a proteolytically cleaved and highly active form of CBS, increasing cystathionine and GSH production (102), which in turn promotes tumor progression and inhibits ferroptosis

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2.7 Parthanayos Parthanayos is a PARP1-dependent, cysteine-dependent cell death pathway characterized by chromosome condensation and DNA fragmentation