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If we are evaluating the plausibility of the hypothesis that TMAO in the blood contributes to heart disease, we care about the total amount of TMAO

This accumulation can have detrimental effects on the health of all living beings, including plants, animals and humans, with far-reaching consequences for marine ecosystems, mariculture activities and fisheries (Phaenark et al., 2024)

Kutcher G, Mohan R, Laughlin J, Barest G, Brewster L, Chui C, Burman C, Fuks Z Three Dimensional Radiation Treatment Planning (IAEA-SM-298/7)

Poor anticoagulation quality in the first 3 months after unprovoked venous thromboembolism is a risk factor for long-term recurrence