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There were no clinically important between-group differences in symptoms, quality of life or safety

191 Snail and Slug can competitively bind to the E-box sequence of the proximal promoter of E-cadherin gene with SMAD-associated protein 1 (SIP1), thereby inhibiting the expression of E-cadherin and inducing EMT in cells

Conclusions and future perspectives PROTACs have revolutionized the entire paradigm of drug discovery and medicinal chemistry research, attracting growing worldwide interest from both academia and the pharmaceutical industry to the extent that articles on PROTACs are published daily

Frequency depends on: Some patients benefit from weekly sessions initially, followed by maintenance infusions