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As MOTS-c activates AMPK and NRF2, it also indirectly suppresses the mTOR (mechanistic target of rapamycin) pathway, the master growth and anabolism regulator that, when chronically overactivated, accelerates the accumulation of senescent cells

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Low-frequency rTMS (1 Hz) applied to this area has reduced the frequency and severity of hallucinations in some patients (van Lutterveld et al., 2012)