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This suggests that DHYZ may alleviate depressive symptoms while inhibiting ferroptosis by modulating the P53/SLC7A11/GPX4 signaling pathway in brain tissue, consequently reducing the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) (Yang et al., 2024)

Thyroid hormones, particularly triiodothyronine (T3) and thyroxine (T4), are transported across the bloodbrain barrier (BBB) by specialized carriers and are metabolically activated or inactivated by local deiodinase enzymes ( Current therapeutic paradigms focus primarily on pharmacological hormone replacement, most commonly levothyroxine (27)