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In Alzheimers disease, this cleanup crew can become exhausted, so some researchers think they can treat the disease by coaxing the cells back into action

Clinical application of proteomics is also becoming increasingly mature, and protein biomarkers are expected to facilitate the assessment of mucosal healing and prognostication [581]

Research conducted in vivo and in vitro has shown that acrolein causes oxidative stress, resulting in the rupture of cell membranes, DNA and mitochondria damage, endoplasmic reticulum (ER) stress, and the potential to initiate apoptosis (112, 113)