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Metabolic disruption is considered one of the most important causes of drug resistance (Lv et al., 2022)

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In breast cancer, where EGFR inhibitors such as erlotinib are being used to inhibit the EGFR signaling pathway, IGF-1R confers resistance by forming one half of a heterodimer (see the description of EGFR signal transduction in the erlotinib page), allowing EGFR signaling to resume in the presence of a suitable inhibitor

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Interaction between DNA damage response and autophagy in colorectal cancer

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