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doi: 10.1007/s10552-004-1809-2

Key points Ammonia accumulates in patients with liver dysfunction owing to its increased production and impaired detoxification by urea cycle enzymes and glutamine synthetase

Emerging therapeutic drug monitoring technologies: considerations and opportunities in precision medicine

In addition, there are many compounds that can induce ferroptosis by inhibiting GPX4, like DPI7 and DPI10 in a directing binding manner and FIN56 in a form that induces GPX4 degradation (Mou et al., 2019