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Site-directed mutations of AC5 in the presence of other divalent cations indicate that the Mg 2+ -binding loci at the AC5 catalytic site are essential for its Ca 2+ -mediated inhibition (Hu et al., 2002

The association between cytoplasmic pattern recognition receptor nucleotide-binding oligomerization domain 2 (NOD2) and the pathogenesis of intestinal diseases has been established (Watanabe et al., 2006

However, as the circadian phenotype of Pc in neuron cluster including LNvs did not fully represent its phenotype in tim -expressing neurons, Pc function in other clock neurons may contribute to circadian regulation

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