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Our early studies demonstrated that vascular dysfunction of epineural arterioles that provide circulation to the sciatic nerve preceded slowing of nerve conduction velocity in streptozotocin-induced diabetes (92, 93)

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Clinical trials of cutaneous neurofibroma from Emerging data from clinical trials of systemic MEK inhibitors suggest that this drug class may play a role in slowing or halting the development of new CNs and/or reducing the size of existing CNs [75]

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Perhaps most concerning is the widespread alteration of androgen receptor gene methylation at 89 CpG sites, potentially modulating AR activity across multiple generations (87)

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After the experiment, wells were checked by eye and any not containing an islet were excluded

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