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However, impaired glutamate uptake breaks this homeostasis, resulting in neuronal excitotoxicity, changes in synaptic plasticity, dysfunction of astrocytes and microglia, and neurodegeneration [73, 74]

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In addition, another four patients developed T2D between 1 and 6.5 years of treatment, and six additional patients developed hyperlipidemia between 5 and 8.5 years ( It is worth mentioning that there have been reports of isolated cases in which bodybuilders developed long-term adverse effects, including squamous cell carcinoma in the lung and bilateral laryngoceles (Moor and Khan, 2005