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This is inseparable from the molecular and functional heterogeneity of CAFs, which depend on various internal and external stimuli to stimulate precursor CAFs to produce different phenotypic features, including myCAF, iCAF, apCAF, and release-related signals, ultimately affecting tumours development ( 3.2 Endothelial cells Vascular endothelial cells adjacent to or distant tumour tissue and bone marrow-derived endothelial progenitor cells, are activated by several regulators to form abnormal vascular mosaicism

Amirahmadi S, Pho M, Gray R, et al