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Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

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Our latest article explores the journey of the naturally occurring plant polyphenols found in Metabolaidfrom digestion and interaction with the gut microbiome to absorption and the cellular signalling pathways researchers continue to investigate