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Strains : aox1 (red dashed line), aox1 , das1 : aox1::TDH3p , PGK1p and das1 (yellow line), aox1 , das1 , das2::TKL1p : aox1 :: TDH3p , PGK1p , das1 and das2 :: TKL1p (dark blue line), aox1 , das1 , das2 : aox1 :: TDH3p , PGK1p , das1 and das2 (blue line) and CBBRuBisCO : aox1 :: TDH3p , PRKp , PGK1p , das1 and das2 :: TPI1p , TKL1p , Each clone was cultivated in duplicates (error bars indicate s.e.m .) and the aox1 control was cultivated as triplicate (error bars show s.d

Median CAGE-B score was 8 (IQR 6 -11), 20% was classified as low, 53% as intermediate and 27% as high risk

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Antioxidants is very important for this phase, to neutralize toxic metabolites as chemicals are broken down