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[10] [11] [12] [13] [14] Rich Van Konynenburg first postulated a depletion of glutathione was at the heart of many of the symptoms of CFS/ME, but quickly added information about methylation when he realized that the two were connected

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However, when the CoA concentration was low, increasing GSNO caused SNO-CoA formation to first increase then decrease, with the yield of other products becoming more dominant when GSNO was present in large excess (Supplementary Fig