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2.5 Data Fitting The reconstructed MRSI data was fitted using LCModel (V6.3-1L, the control file can be found in the Supplementary Material) 37 with a basis set simulated with VeSPA (version 0.9.5 38 ) consisting of the following basis spectra: aspartate (Asp), -aminobutyric acid (GABA), glycine, glutathione (GSH), myo-Inositol (mI), NAAG, scyllo-inositol (scyllo), taurine (Tau), Glc, Glu, Gln, NAA, total creatine (tCr), total choline (tCho) and a simulated macromolecular baseline (MM)

KPV exerts its primary anti-inflammatory activity through direct intracellular penetration of immune cells and intestinal epithelial cells, where it suppresses NF-B transcription factor activity the master regulator of pro-inflammatory cytokine gene expression through a receptor-independent intracellular mechanism, resulting in downstream reduction of IL-6, IL-8, TNF-, and related inflammatory mediators

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