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Epigenetic Modification Prevents Excessive Wound Healing and Scar Formation After Glaucoma Filtration Surgery

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Results: Transcriptomic analysis of KC and infiltrating liver M, brain microglia & BM MO revealed common as well as uniquely differentially expressed genes (DEG) in response to age (Fig A) and/or alcohol (Fig B & C)

As shown in Figures 4L, M, erastin significantly reversed the effect of Sat1 knockdown on TFR1 and GPX4 protein expression, but it did not affect the protein expression of SAT1, which revealed that SAT1 was the upstream regulator of ferroptosis