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Polymersomes Synthetic vesicular structures, analogous to liposomes, that are formed in solution by self-assembly of amphiphilic copolymers

Mar-Apr 2011;77(2):128-134

Deleterious off-target effects in women 10 years or more past menopause, such as ovarian, endometrial, and breast cancers, intravascular thrombosis, cardiovascular episodes, and stroke, and suppression of endogenous testosterone and libido and increased risk of prostate cancer in men, have precluded broad clinical applications (Stevenson and Thornton, 2007)

mTORC1 activity is enabled by the binding of its subunit Raptor to Rag proteins on the lysosome, as part of its nutrient-sensing functions 7,8