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4 Challenges for establishing high-fidelity BRAF V600E tumor models 4.1 The challenges of developing models for low-grade gliomas Establishing robust in vitro models that are representative of low-grade CNS tumors, incuding BRAF V600E -mutated CNS tumors is inherently challenging

[56] Oxidative stress can cause DNA damage in neurons

Moreover, the Bmal1:Clock transcriptional complex increases the expression of genes encoding adipose triglyceride (TG) lipase and hormonesensitive lipase, thereby regulating the lipolysis rate throughout the circadian cycle [52]

Short and mild increases in IOP may induce reactive activation of Mller cells, astrocytes and microglia prior to significant RGC/axonal damage