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This is supported by reduced plasma levels of endogenous antioxidants, including S-adenosylmethionine (Frye et al., 2013a

However, (i) medical ozone treatment (O 3 T) must specifically avoid the inhalation of ozone, and (ii) an appropriate ozone concentration and route of administration look for the induction of a controlled, limited and transient oxidative stress that can overregulate nuclear factor erythroid 2-related factor 2 (Nrf2), which is the key for a further enhancement of the antioxidant defenses in the body with further and favorable modulation of oxidative stress and inflammation (Re et al., 2014

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